An American Werewolf in London (1981)

Two American friends backpacking in England are attacked by a werewolf, leaving one dead and the other cursed with lycanthropy. As the surviving friend struggles to come to terms with his new reality, he must navigate the dangerous repercussions of his friend's death and his own transformation into a werewolf. Directed by John Landis, "An American Werewolf in London" is known for its groundbreaking special effects and blending of horror and dark humor.